Application
Ion Exchange Resins for
Pharmaceutical & Biotechnology
Samyang's TRILITE® pharmaceutical and biotechnology resins are applied in the optimal grade according to the characteristics of the target substance, and are used together with synthetic adsorbents in a wide range of bio and chemical purification processes.
Key Features
Electrolytes that dissociate into ions in water are separated with ion exchange resins, while uncharged substances are separated with synthetic adsorbents that exploit differences in molecular weight and polarity. Amphoteric electrolytes, whose charge changes with pH, can be separated by either method. The three representative separation methods using TRILITE® are as follows.
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Separation of Non-Electrolytes and Electrolytes
This process uses cation and anion exchange resins to remove ionic impurities contained in non-electrolyte substances. The target non-electrolytes, such as starch sugars, pass through the resin bed, while cationic and anionic impurities are selectively removed.
· Applicable processes : Starch sugar refining, sugar refining, sorbitol refining, glycerin refining, gelatin refining -
Separation of Amphoteric Electrolytes
Amphoteric electrolytes are substances that can carry both positive and negative charges depending on pH. They are separated by adsorbing them onto an ion exchange resin at a pH away from the isoelectric point, then selectively eluting them by adjusting the pH.
· Applicable processes : Amino acid purification, protein purification, peptide purification -
Separation based on differences in molecular weight or hydrophilicity/hydrophobicity
This process applies synthetic adsorbents to substances that carry no charge and are therefore difficult to separate by ion exchange. Synthetic adsorbents have no ion exchange groups, but adsorb organic substances through van der Waals forces via their large specific surface area and pores; the grade is selected according to the molecular weight and polarity of the target substance.
· Applicable processes : Protein purification and separation, antibiotic extraction and purification, purification of functional food additives
- ※ Electrolytes
- Substances that dissolve in a solvent such as water and dissociate into ions, allowing electric current to flow.
Generally, substances that can be exchanged with ion exchange resins are collectively referred to as electrolytes.
Product
Selection Guide
Product
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